Some scientific evidence supports the use of Vitamin E, particularly in topical forms, for the management of psoriasis. Vitamin E is a fat-soluble antioxidant known to protect skin cells from oxidative stress, which is believed to be involved in the pathogenesis of psoriasis. Several small studies and clinical trials have evaluated the effects of Vitamin E (often combined with other antioxidants or vitamins) applied topically or taken orally.

For example, a randomized, double-blind study (Jemec et al., 1999) found that topical Vitamin E acetate improved mild to moderate plaque psoriasis compared to placebo. Other studies have investigated oral supplementation, sometimes in combination with Vitamin C and selenium, with mixed results—some reporting modest improvement and others showing little benefit.

While Vitamin E is generally considered safe and may provide some symptomatic relief due to its anti-inflammatory and moisturizing properties, the overall quality and quantity of evidence is limited. Most guidelines do not recommend Vitamin E as a primary or stand-alone therapy for psoriasis. More robust and larger-scale trials are needed to confirm its efficacy and clarify optimal dosing and formulation. Current use is often adjunctive, and patients should consult healthcare professionals before initiating Vitamin E supplementation for psoriasis.