Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (gamma tocopherol) has been explored as a supportive treatment for psoriasis, primarily due to its antioxidant and anti-inflammatory properties. Scientific interest is mostly focused on the role of oxidative stress in psoriasis pathogenesis, and Vitamin E’s ability to neutralize free radicals. Several small clinical trials and case studies have investigated the effects of Vitamin E supplementation (usually as alpha-tocopherol, with less data on gamma-tocopherol specifically) in patients with psoriasis.

Some studies have reported mild improvements in erythema, scaling, and overall skin lesion severity when Vitamin E is used alone or as an adjunct to standard therapies. The mechanism is hypothesized to involve reduction of oxidative damage and modulation of inflammatory pathways. However, evidence is limited by small sample sizes, short study durations, inconsistent dosing, and a lack of large, well-controlled trials. The majority of research uses mixed tocopherols or alpha-tocopherol, with direct evidence for gamma-tocopherol’s effect in psoriasis being sparse.

Given this, the use of Vitamin E (gamma tocopherol) is supported by a modest amount of scientific evidence, but it is not considered a primary or standalone therapy for psoriasis. Larger and more rigorous trials are needed to clarify its efficacy and optimal formulation. At present, it may be considered as a supplementary option for patients, but clinicians should be cautious in making strong recommendations based on current data.

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