Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin is a flavonoid found in many fruits and vegetables, known for its antioxidant and anti-inflammatory properties. Its use in supporting or treating psoriasis is primarily justified by early-stage scientific research, mostly preclinical (cell and animal studies), with limited human data. Psoriasis is a chronic, immune-mediated inflammatory skin disorder characterized by overproduction of skin cells and inflammation. Laboratory studies have shown that quercetin can inhibit the release of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-17, which play significant roles in the pathogenesis of psoriasis. Additionally, quercetin has demonstrated the ability to reduce oxidative stress and suppress immune cell activation in experimental models, which may help alleviate the symptoms of psoriasis.

However, clinical evidence in humans remains sparse. Some small pilot studies and case reports suggest topical or oral quercetin might reduce the severity of psoriatic lesions and inflammation, but these studies often lack rigorous controls and have small sample sizes. No large-scale randomized controlled trials have definitively confirmed its efficacy or safety for psoriasis patients. Thus, while there is a plausible scientific rationale and promising preliminary data, current evidence does not robustly support quercetin as a mainstream or primary therapy for psoriasis.

In summary, quercetin's use for psoriasis is supported by basic science and limited early clinical evidence, but stronger, high-quality human data are needed before its role can be established in clinical practice.

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