Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Exopeptidases are enzymes that catalyze the removal of terminal amino acids from the ends of protein chains, playing a crucial role in protein digestion. Their use to support or treat poor protein digestion is supported by scientific evidence. In the human gastrointestinal tract, both endogenous (produced by the body) and exogenous (supplemental) exopeptidases contribute to breaking down dietary proteins into absorbable amino acids and small peptides. Scientific studies have demonstrated that supplementation with exogenous proteolytic enzymes, including exopeptidases, can enhance protein digestion, particularly in individuals with pancreatic insufficiency or other digestive disorders that impair endogenous enzyme production.

Clinical trials have shown that protease enzyme supplements can improve protein absorption and reduce gastrointestinal symptoms such as bloating and discomfort in people with compromised digestive function. While most commercial digestive enzyme supplements contain a mixture of endopeptidases (which cleave proteins internally) and exopeptidases, the exopeptidase component specifically aids in the final stages of protein breakdown. The efficacy of these supplements is well documented in the context of certain medical conditions, such as exocrine pancreatic insufficiency, and there is a plausible mechanistic rationale for their broader use in cases of poor protein digestion.

However, for healthy individuals, the benefit of additional exopeptidase supplementation is less clear, as the body typically produces sufficient enzymes. Overall, the use of exopeptidase for supporting protein digestion in cases of deficiency or impaired function is scientifically validated and supported by moderate to strong clinical evidence.

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