Quercetin is a plant flavonoid found in many fruits and vegetables, and it has been investigated for its potential role in supporting prostate health, particularly in the context of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Multiple double-blind, placebo-controlled clinical trials have shown that quercetin supplementation (typically 500 mg twice daily) can significantly reduce symptoms in men with CP/CPPS, as measured by validated symptom indices. For example, a pivotal study published in Urology (1999) demonstrated that 67% of men taking quercetin reported significant improvement in symptoms compared to 20% in the placebo group. The proposed mechanisms include quercetin’s anti-inflammatory, antioxidant, and mast cell-stabilizing properties, which may help mitigate inflammation and pain within the prostate and surrounding tissues. While quercetin is not a standard therapy for benign prostatic hyperplasia (BPH) or prostate cancer, it is sometimes used as an adjunct for inflammatory and pain-related prostate conditions. The current clinical evidence is limited to small-to-moderate sized trials and further large-scale studies are needed, but the existing data provides a reasonable scientific basis for its use in supporting prostate health, particularly for CP/CPPS.