Evidence supporting the use of: Lignans
For the body system: Prostate

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lignans are a group of polyphenolic compounds found in plants, especially in flaxseed, sesame seeds, and whole grains. Their use for prostate health is primarily justified by emerging scientific evidence, although most research is preclinical or observational in nature. Lignans are phytoestrogens, meaning they can have weak estrogen-like effects in the body and may influence hormone metabolism.

Several studies have suggested that lignans and their metabolites (such as enterolactone and enterodiol) may have a protective effect against prostate cancer development by modulating hormone levels, reducing oxidative stress, and exerting anti-inflammatory effects. For example, some epidemiological studies have found that higher dietary intake of lignans or higher circulating levels of enterolactone are associated with a lower risk of prostate cancer. However, results are not entirely consistent, and clinical trials in humans are limited and have shown mixed results regarding lignan supplementation's actual effect on prostate size, symptoms, or cancer risk.

Overall, while the biological plausibility and some observational data support potential benefits, the current body of evidence is not strong or conclusive. More rigorous, large-scale clinical trials are needed to establish a direct benefit of lignans for prostate health.

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