Evidence supporting the use of: Total Fat
For the body system: Prostaglandins

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Total Fat, particularly dietary fats that include essential fatty acids such as omega-3 and omega-6 polyunsaturated fatty acids, is scientifically validated to support prostaglandin synthesis in the body. Prostaglandins are lipid compounds derived enzymatically from fatty acids and are critical in numerous physiological functions, including inflammation, immunity, and regulation of cell growth. The body cannot synthesize essential fatty acids de novo; therefore, they must be obtained through the diet. Linoleic acid (omega-6) and alpha-linolenic acid (omega-3) are direct precursors for the biosynthesis of various prostaglandins via the cyclooxygenase (COX) pathways. Multiple studies have shown that the type and amount of fat consumed in the diet can influence the balance and production of prostaglandins, impacting processes such as inflammation and vascular tone. For example, increased intake of omega-3 fatty acids is associated with a shift towards prostaglandins that are less inflammatory. Thus, there is robust biochemical and clinical evidence supporting the role of total fat, especially its quality and composition, in modulating prostaglandin synthesis and activity in the human body.

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