Evidence supporting the use of: Linoleic Acid
For the body system: Prostaglandins

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Linoleic acid is an essential omega-6 polyunsaturated fatty acid that plays a crucial role in the synthesis of prostaglandins, which are bioactive lipid compounds involved in inflammation, immunity, and various physiological processes. The pathway begins with linoleic acid being converted to arachidonic acid, which is the direct precursor to several classes of prostaglandins via the cyclooxygenase (COX) and lipoxygenase (LOX) pathways. Multiple scientific studies have demonstrated the necessity of dietary linoleic acid for maintaining adequate arachidonic acid levels, and consequently, for normal prostaglandin production. For example, a deficiency in linoleic acid can lead to impaired prostaglandin synthesis and associated physiological dysfunctions, such as altered inflammation and immune responses (PMID: 21518682). However, while the biochemical pathway is well established, the therapeutic use of supplemental linoleic acid to modulate prostaglandin-mediated processes is more nuanced, as excess omega-6 fatty acid intake may promote pro-inflammatory prostaglandin production. Overall, the evidence supports the essential role of linoleic acid in prostaglandin biosynthesis, but clinical applications require careful consideration of the broader balance of dietary fatty acids.

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Products containing Linoleic Acid

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