Evidence supporting the use of: Isoflavones (mixed)
For the health condition: PMS (general)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Isoflavones, primarily found in soy and other legumes, are phytoestrogens—plant compounds structurally similar to human estrogens. Their use for premenstrual syndrome (PMS) is based on their ability to bind to estrogen receptors, potentially modulating hormonal fluctuations associated with PMS symptoms. Several small randomized controlled trials and observational studies have explored the effects of isoflavones on PMS symptoms, with mixed results. Some studies suggest modest improvements in certain symptoms like mood swings, breast tenderness, and bloating, likely due to the weak estrogenic (or anti-estrogenic) activity of isoflavones. However, the overall quality of evidence is low, with limitations including small sample sizes, short study durations, and heterogeneity in isoflavone preparations and dosages.

Systematic reviews and meta-analyses of isoflavones for menopausal symptoms show more consistent evidence of benefit, but their applicability to PMS is limited, as the pathophysiology differs between PMS and menopause. Major guidelines do not currently recommend isoflavones as a first-line or proven therapy for PMS. Nevertheless, the biological plausibility and limited but suggestive clinical evidence mean that isoflavones are sometimes used for PMS, especially in integrative or complementary medicine contexts. In summary, scientific evidence supporting isoflavones for PMS is weak but present, justifying a low-moderate rating.

More about Isoflavones (mixed)
More about PMS (general)

Products containing Isoflavones (mixed)

We currently have no products on Caring Sunshine that contain this ingredient.