Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-arginine is an amino acid that serves as a precursor for the synthesis of nitric oxide and plays a role in several metabolic pathways, including those influencing hormone secretion. Its use to support the anterior pituitary is primarily based on its ability to stimulate the release of growth hormone (GH). Scientific studies have shown that oral or intravenous administration of L-arginine can acutely increase plasma GH levels in both children and adults. This is thought to occur because L-arginine suppresses somatostatin, a hormone that inhibits GH release, thereby promoting increased secretion of GH from the anterior pituitary.

Clinically, the L-arginine stimulation test is used to diagnose growth hormone deficiency, further indicating its influence on the pituitary’s function. However, while there is clear evidence that L-arginine can stimulate GH secretion acutely, there is limited evidence supporting its use for long-term enhancement of pituitary function or for general pituitary health in healthy individuals. Most studies focus on its application in diagnostic settings or specific patient populations (e.g., those with GH deficiency), rather than as a general supplement for pituitary support.

Therefore, while there is scientific validation for its acute effects on the anterior pituitary—primarily growth hormone release—the overall evidence for broader pituitary support is limited, justifying a moderate evidence rating.

More about l-arginine
More about Pituitary (anterior)

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