Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Turkey tail mushroom (Trametes versicolor) is known for its polysaccharopeptides (PSP and PSK), which have been studied for their immunomodulatory effects. Scientific research indicates that these polysaccharides can enhance immune function by stimulating various immune cells, including macrophages, dendritic cells, and T lymphocytes. Peyer’s patches are important immune surveillance sites in the gut-associated lymphoid tissue (GALT), where immune cells monitor pathogens and maintain gut immunity. Several in vitro and animal studies have demonstrated that polysaccharides from turkey tail mushrooms can stimulate activity and proliferation of immune cells in the gut, including those associated with Peyer’s patches. For instance, studies have shown increased IgA production and enhanced macrophage and lymphocyte activity in the gut after administration of turkey tail extracts.

However, while there is mechanistic evidence from animal and cellular studies showing that turkey tail polysaccharides can activate immune functions relevant to Peyer’s patches, robust clinical data in humans directly linking turkey tail supplementation to improved function of Peyer’s patches specifically is limited. Most human studies focus on broad immune enhancement or cancer support. Thus, the evidence base is moderate and largely preclinical, but there is scientific rationale for its use in supporting gut-associated immune tissues like Peyer’s patches.

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