Evidence supporting the use of: Oligosaccharide
For the body system: Peyer’s patches

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Oligosaccharides, particularly prebiotic types such as fructooligosaccharides (FOS), galactooligosaccharides (GOS), and inulin, have been scientifically investigated for their effects on gut-associated lymphoid tissue (GALT), which includes Peyer’s patches. Peyer’s patches are important lymphoid nodules in the small intestine that play a critical role in immune surveillance and the generation of immune responses to antigens present in the gut. Several animal and in vitro studies indicate that dietary oligosaccharides can modulate immune function, in part by promoting the growth of beneficial gut microbiota (such as Bifidobacterium and Lactobacillus species), which in turn can influence the development and activity of immune cells within Peyer’s patches.

Preclinical studies have shown that supplementation with certain oligosaccharides can increase the number and activity of immune cells in Peyer’s patches, enhance IgA production, and improve mucosal immunity. For example, a 2003 study in mice found that GOS supplementation led to increased IgA-secreting cells in the intestinal mucosa and Peyer’s patches. While direct human evidence is limited, some human trials suggest that prebiotics may enhance systemic and mucosal immune parameters, likely via effects on gut microbiota and GALT. However, more robust clinical data are needed to confirm specific effects on Peyer’s patches in humans. In summary, there is moderate scientific evidence from animal and mechanistic studies supporting the use of oligosaccharides to modulate immune functions associated with Peyer’s patches.

More about Oligosaccharide
More about Peyer’s patches

Products containing Oligosaccharide

We currently have no products on Caring Sunshine that contain this ingredient.