Evidence supporting the use of: Mannan
For the body system: Peyer’s patches

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Mannan, specifically in the form of mannose-rich polysaccharides such as mannan-oligosaccharides (MOS), has been investigated for its potential to support the immune system, including its interaction with Peyer’s patches in the gut-associated lymphoid tissue (GALT). Peyer’s patches are critical sites for immune surveillance and the initiation of immune responses in the intestines. Several animal studies, particularly in poultry and swine, have demonstrated that dietary supplementation with MOS can enhance the activity and number of immune cells within Peyer’s patches. This is thought to occur because MOS mimics certain pathogen-associated molecular patterns, stimulating immune responses, and may bind to gut pathogens, preventing their adherence and facilitating their uptake and presentation by Peyer’s patches. Additionally, in vitro studies suggest MOS can modulate the production of secretory IgA, an important antibody in mucosal immunity, with Peyer’s patches being a key site for IgA synthesis. However, most scientific evidence comes from animal research, with limited direct clinical trials in humans. While there is a mechanistic rationale and supportive preclinical data, robust human evidence is still lacking, justifying a moderate evidence rating.

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Products containing Mannan

We currently have no products on Caring Sunshine that contain this ingredient.