Evidence supporting the use of: Bifidobacterium longum
For the body system: Peyer’s patches

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bifidobacterium longum is a well-studied probiotic species known for its beneficial effects on gut health and immune modulation. Peyer's patches are specialized lymphoid tissues in the small intestine that play a crucial role in gut-associated immune responses. Scientific research, primarily in animal models and in vitro studies, has shown that Bifidobacterium longum can interact with the gut-associated lymphoid tissue, including Peyer’s patches, to stimulate immune responses.

Specifically, studies have demonstrated that administration of B. longum can increase the activity of antigen-presenting cells and promote the secretion of immunoglobulin A (IgA) in the gut, a process that is largely orchestrated by Peyer's patches. Some evidence indicates that B. longum enhances the number and function of IgA-secreting cells in Peyer’s patches, thereby supporting mucosal immunity and helping maintain intestinal barrier function.

However, it is important to note that while there is a plausible mechanistic basis and preclinical support for this effect, direct evidence in human clinical trials specifically linking B. longum supplementation to improved functioning of Peyer’s patches is limited. Most human studies focus on broader immune or gut health outcomes. Thus, while the use of B. longum for supporting Peyer’s patches is scientifically plausible and partially substantiated, more direct human evidence is required for a higher confidence rating.

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