Evidence supporting the use of: Vitamin B12 (deoxyadenosylcobalamin)
For the health condition: Pernicious Anemia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Vitamin B12 (deoxyadenosylcobalamin) is used to treat and support Pernicious Anemia based on robust scientific evidence. Pernicious anemia is an autoimmune disorder characterized by the destruction of gastric parietal cells, resulting in a deficiency of intrinsic factor—a protein essential for the intestinal absorption of vitamin B12. Without intrinsic factor, vitamin B12 from dietary sources cannot be efficiently absorbed, leading to a deficiency that impairs DNA synthesis and red blood cell production.

Vitamin B12 is vital for normal hematopoiesis, neurological function, and DNA synthesis. The classic symptoms of pernicious anemia—megaloblastic anemia, glossitis, and neurological disturbances—are directly attributable to B12 deficiency. Scientific studies and clinical trials have demonstrated that parenteral (intramuscular or subcutaneous) administration of vitamin B12 bypasses the need for intrinsic factor and effectively reverses both hematologic and neurological manifestations of the disease.

The standard treatment for pernicious anemia is regular intramuscular injections of vitamin B12, often initially as cyanocobalamin or hydroxocobalamin, but deoxyadenosylcobalamin, an active coenzyme form, is also effective. This therapy is supported by decades of clinical experience and is recommended by major medical guidelines. Oral supplementation is less effective for most patients due to impaired absorption, but high-dose oral therapy can sometimes be used. In summary, the use of vitamin B12 to treat pernicious anemia is justified by strong scientific validation and is considered the standard of care.

More about Vitamin B12 (deoxyadenosylcobalamin)
More about Pernicious Anemia

Other health conditions supported by Vitamin B12 (deoxyadenosylcobalamin)

Anemia
Depression
Fatigue
Memory and Brain Function
Peripheral Neuropathy
Pernicious Anemia

Products containing Vitamin B12 (deoxyadenosylcobalamin)

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