Evidence supporting the use of: Vitamin D (mixed)
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D has been investigated for its potential role in supporting patients with Parkinson's Disease (PD). Several observational studies have reported that individuals with PD often have lower serum vitamin D levels compared to healthy controls, and low vitamin D status has been associated with increased risk of developing PD and with greater severity of motor symptoms. The biological rationale centers on vitamin D’s roles in neuroprotection, regulation of calcium homeostasis, reduction of neuroinflammation, and modulation of immune response—mechanisms that may be relevant in the pathogenesis and progression of PD.

However, the evidence for clinical benefit is limited. Randomized controlled trials (RCTs) have been few and generally small. A 2013 RCT (Suzuki et al.) found that vitamin D supplementation slowed the progression of motor symptoms in early PD, but subsequent studies have not consistently replicated these findings. Systematic reviews and meta-analyses conclude that while vitamin D deficiency is common in PD and may be associated with worse outcomes, there is insufficient high-quality evidence to recommend supplementation specifically for PD symptom treatment or progression. Current guidelines do not endorse vitamin D as a disease-modifying therapy for PD, though correcting deficiency is considered good general practice for bone and overall health. Thus, scientific interest exists, but robust validation is lacking.

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