Evidence supporting the use of: Phytocannabinoid (unspecified)
For the body system: Parasympathetic Nervous System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Phytocannabinoids, notably compounds like cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), are naturally occurring substances found in cannabis plants. Scientific research has demonstrated that these compounds interact with the body's endocannabinoid system—a regulatory network that interfaces with both the sympathetic and parasympathetic branches of the autonomic nervous system. Preclinical and limited clinical studies indicate that certain phytocannabinoids may promote parasympathetic (rest-and-digest) activity, primarily by modulating neurotransmitter release and reducing stress responses mediated by the sympathetic nervous system.

For example, animal studies have shown that CBD can decrease heart rate and blood pressure in stressful situations, suggesting a shift towards parasympathetic dominance. Human studies are less conclusive but do report anxiolytic and calming effects of CBD, which may reflect increased parasympathetic tone. The mechanism is thought to involve actions on CB1 and CB2 receptors as well as serotonin receptors.

However, the evidence base is still developing, and most studies use specific, well-characterized phytocannabinoids rather than "unspecified" mixtures. There is moderate scientific support for the use of certain phytocannabinoids to support parasympathetic activity, but more rigorous, large-scale clinical studies are needed to fully establish efficacy and safety for this purpose.

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