Evidence supporting the use of: Oxytocin
For the body system: Parasympathetic Nervous System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Oxytocin is a neuropeptide hormone primarily known for its roles in childbirth and lactation, but it also has significant effects on the central nervous system, including modulation of the autonomic nervous system. There is scientific evidence suggesting that oxytocin can support parasympathetic nervous system activity. Research has shown that oxytocin administration can enhance vagal (parasympathetic) tone, as measured by heart rate variability, and can reduce markers of sympathetic nervous system activation, such as cortisol levels and blood pressure. These effects are likely mediated through oxytocin’s action on the central nervous system, where it can promote relaxation, reduce anxiety, and foster social bonding—all processes associated with increased parasympathetic activity.

Clinical studies have investigated intranasal oxytocin and found effects consistent with enhanced parasympathetic function, such as decreased heart rate and increased feelings of calmness or well-being. However, much of the research is still in early stages, and most studies have been conducted in controlled experimental or clinical settings rather than in the context of routine medical support for the parasympathetic nervous system. In summary, there is credible scientific evidence that oxytocin can modulate the autonomic nervous system and support parasympathetic activity, but its use for this purpose outside of research or specific clinical scenarios is not yet widely established.

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