Synopsis

Source of validity: Scientific
Rating (out of 5): 2

GABA (gamma-aminobutyric acid) is best known as the principal inhibitory neurotransmitter in the central nervous system, where it plays a crucial role in reducing neuronal excitability and promoting relaxation and calm. The parasympathetic nervous system (PNS), often described as the "rest and digest" system, promotes relaxation and recuperative processes in the body. The rationale for using GABA supplements to support the PNS is based on GABA’s calming effects in the brain, which are thought to mimic or support the effects of increased parasympathetic activity. However, the scientific evidence supporting oral GABA supplementation for directly enhancing parasympathetic nervous system function is limited. While some small studies have indicated that GABA supplementation may promote relaxation and reduce markers of stress, there is ongoing debate about whether orally ingested GABA crosses the blood-brain barrier in significant amounts to exert central nervous system effects. Some research suggests peripheral effects (e.g., on heart rate variability) that may indicate increased parasympathetic tone, but these findings are preliminary and not robust. Overall, while the biological plausibility exists and there is some initial evidence, the scientific validation for GABA supplementation as a means to support the parasympathetic nervous system specifically is modest and not conclusive, warranting a rating of 2 out of 5.

More about GABA (gamma aminobutyric acid)
More about Parasympathetic Nervous System

Other ingredients that support Parasympathetic Nervous System

Other body systems supported by GABA (gamma aminobutyric acid)

Products containing GABA (gamma aminobutyric acid)

Nature's Sunshine Gaba Plus