DHA-conjugated phosphatidylserine (DHA-PS) has some scientific evidence supporting its use for nervous system health, including potential benefits to the parasympathetic nervous system (PNS), though the evidence is not robust or highly specific to the PNS. Phosphatidylserine (PS) is a phospholipid found in high concentrations in neuronal membranes and is involved in cell signaling and neuroprotection. Docosahexaenoic acid (DHA), an omega-3 fatty acid, is also vital for neuronal membrane fluidity and function.

Research demonstrates that PS supplementation (including forms conjugated with omega-3s like DHA) can enhance cognitive function and may reduce stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis, which indirectly relates to parasympathetic activity by modulating the balance between sympathetic and parasympathetic responses. Some studies suggest PS and DHA-PS may help regulate cortisol levels and improve mood, attention, and memory, which are associated with overall autonomic balance.

However, direct evidence specifically linking DHA-PS to targeted enhancement of the parasympathetic nervous system is limited. Most research focuses on general brain health, cognitive function, and stress response rather than selective support for the PNS. Thus, while there is a scientific rationale for its use in nervous system support broadly, specific validation for parasympathetic function is moderate.