Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Microbial enzymes are used to support the pancreas’ digestive function, as the pancreas produces key digestive enzymes (amylase, protease, lipase) that help break down carbohydrates, proteins, and fats. Microbial enzymes—typically derived from fungi such as Aspergillus oryzae or Rhizopus oryzae—are widely used in digestive enzyme supplements as alternatives to porcine or bovine pancreatic enzymes. Several clinical studies and systematic reviews support the efficacy of microbial enzymes in enhancing digestion, particularly in people with exocrine pancreatic insufficiency (EPI), a condition where the pancreas does not secrete enough enzymes. For example, studies have shown that microbial-derived enzymes can improve fat and protein digestion and reduce gastrointestinal symptoms in EPI patients. The U.S. FDA recognizes certain microbial enzymes as Generally Recognized as Safe (GRAS), acknowledging their established safety profile. However, while there is robust evidence for their use in pancreatic insufficiency, evidence for use in healthy individuals is less conclusive. Overall, the scientific literature supports the use of microbial enzymes to compensate for deficient pancreatic enzyme production, justifying their inclusion in supplements intended to support the pancreas and digestive health.

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