Evidence supporting the use of: Vitamin D
For the health condition: Pain (general remedies for)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D has been investigated for its role in supporting or treating various forms of pain, especially musculoskeletal pain. Several observational studies have found a correlation between low vitamin D levels and increased incidence of chronic pain conditions, such as fibromyalgia, chronic low back pain, and general musculoskeletal discomfort. Some randomized controlled trials (RCTs) suggest that vitamin D supplementation may reduce pain in individuals who are deficient, particularly in specific populations such as older adults or those with known deficiency.

However, the evidence is mixed. While some RCTs report modest improvements in pain symptoms with vitamin D supplementation, others find no significant benefit compared to placebo. Systematic reviews and meta-analyses generally conclude that vitamin D supplementation may help relieve pain in people with low baseline vitamin D levels but is unlikely to alleviate pain in those with adequate levels. The proposed mechanisms include vitamin D’s role in modulating inflammation, neuromuscular function, and immune system activity, which can all influence pain perception.

In summary, there is some scientific evidence—though not strong—for the use of vitamin D in supporting pain relief, particularly for those who are vitamin D deficient. Routine supplementation for pain is not widely recommended unless deficiency is demonstrated. The evidence is rated as moderate to low (2/5) due to inconsistent study results and limited high-quality trials.

More about vitamin D
More about Pain (general remedies for)

Other ingredients used for Pain (general remedies for)

allspice
alpha-pinene
arjun tree
ashwagandha
waterhyssop
bamboo
barberry
myrobalan
benegut perilla (proprietary)
beta caryophyllene
beta-pinene
betel
bisabolol
black pepper
radish
Indian frankincense
bromelain
bupleurum falcatum
burdock
cabbage leaf
California poppy
camu camu
cassia bark
celery
chen pi
cherry
Chinese salvia root
chymotrypsin
cissus quadrangularis
collagen
cordyceps
turmeric
curcumin
devil's claw
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
dog rose
ethanol
fennel
fenugreek
flaxseed
fruit blend (proprietary)
gelatin
ginger
gooseberry
gotu kola
honeysuckle
Japanese sophora
jujube
kudzu
l-phenylalanine
lovage
magnesium
methylsulfonylmethane (MSM)
mint
nettle
spruce
okra
orange
peppermint oil
perilla
polygala root
protease
pumpkin
quail egg
reishi mushroom
rose oil
rutin
saffron
sage
black ginger
specialized pro-resolving mediators (SPMs)
strawberry
vitamin D
watercress
mulberry
white willow
zhejiang fritillary
sarsaparilla
yellow root
boneset
catnip
typhonium
hyssop
cardamom
atractylodes
alpinia galangal
clerodendrum indicum
hedychium spicatum
inula racemosa
anise
pistacia integerrima gall
paederia foetida
smilax
fumaria parviflora
rubia cordifolia
swertia
chaff flower
lingusticum wallichii
goldenrod
yarrow
prickly ash
morus
root tuber
silk tree
haliotis
juniper berries
solomon's seal
amber
flowering quince
cistanche
dioscorea
teasel
sweetgums
lotus seed
birch
queen of the meadow
anemarrhena asphodeloides
purslane
yucca
barrenwort
wintergreen
camphor oil
aster root
gentiana macrophylla
shepherd's purse
yerba mate
fungal enzymes blend (proprietary)
peach
noni
wood betony
biota seed
white oak
abies spectabilis
Sichuan pepper
soursop
geranium
arnica
clematis
sea salt
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Alcohol
Aralia
Arjuna
akebia
Antler
Agastache
Alseodaphne andersonii
Angel's Trumpet
Aquilegia viridiflora
Alpha-Humulene
Alpha-terpineol
Agrimony
Antrodia camphorata
Achyranthes
Auricularia
Abrus
Alchornea
American Pawpaw
Amomum
Asarum heterotropoides
Albizia
Alchemilla
Aconite
Asafoetida
Ajuga
Aucubin
Andrographolide
Anserina
Agmatine
Aerva lanata
Agarwood
American Liverleaf
Anemone
Aquilegia formosa
Asam gelugor
Angostura
Andrographis
Alsonia scholaris
Actaea spicata
Agonandra
Agrimonia pilosa
Acetylsalicylic acid
Acer Truncatum bunge
Arjunic Acid
allyl isothiocyanate
Aspen
Ashoka
Argan nut oil
Asarabacca
Abuta
Alstonia macrophylla
Amor seco
Arani
Arisaema
Atractylone
Betony
Baikal Skullcap
Blue Flag
Bryonia
Baliospermum
Black spruce
Blackthorn
Bleeding Heart
Bulnesia sarmientoi
bergenin
Blubber oil
Breadnut
Blepharis
Boswellic Acid
Bistort
Baccharis dracunculifolia
Barleria
Berberis (unspecified)
Bougainvillea
Brazillian peppertree
Bugbane
Bisabolene
Benfotiamine
Bael
Butternut
Bogbean
Black Gram
Bauhinia
Boswellia
Bethroot
Banyan
Black willow
Ba Ji Tian
Barbasco
Barbary matrimony vine
Borassus aethiopum
Borage
Black root
Baobab
Bupleurum
Bittersweet
Bassia scoparia
Burning Bush
Black Hellebore
Bee venom
Bergenia
Bottle gourd
Cumin
Centella triterpenes
Calendula
Casearia esculenta
Common Monkey Flower
Chinese Mountain Ant
California Redbud
Calotropis gigantea
Carrapicho
Cucurbita
Codonopsis
Cnidium
Clerodendrum phlomidis
Cactus
Cynomorium
Cinquefoil
Cyathula
Citron
Cashew
Chinese Fleeceflower
Cymbidium goeringii
Cannabinol
Cramp Bark
Chinese Pond Turtle
Cajuput
Chuchuhuasi
Cymbopogon Martini
Centella asiatica
Coca
Capers
Celandine
Cinnamic Acid
Ceylon Leadwort
Cetylated Fatty Acids
Cissus sicyoides
Chinese Ligustrum berry
Campylandra fimbriata
Chenopodium
Chilean Wildnut
Cistus
Corktree
Cubeb
cypress
Cowslip
Cranesbill
Crinum latifolium
Chaenomeles lagenaria
Cannabidiol
Carlina
Calamus
Cherimoya
Cyanthillium cinereum
Corydalis
Cynodon dactylon
Chiococca alba
Collinsonia
Celastrus
Copaiba Oil
Colocynth
cola nut
Cynanchum
California False Hellebore
Cupuacu
Casearia sylvestris
Culvers Root
Currant
Calycophyllum
Cannabidiolic acid
Dimorphandra mollis
D-phenylalanine
Didymocarpus
Dendrobine
DIVI-DIVI
Dicentra formosa
Danshen
Dense Fruit Dittany
Deer Root
Dodeca-2E, 4E-Dienoic Acid Isobutylamide
Dill
Dianthrone
Dwarf Morning Glory
Dolichos
Dimethyl sulfoxide (DMSO)
Dimorphandra gardneriana
Dipsacus
Dodeca-2E, 4E, 8Z, 10Z/Etetraenoic Acid Isobutylamide
European Elder
Erythropalum scandens
Erigeron
English Horsemint
Erythrina
Elk antler
Emblicanin
Emu Oil
Echinodorus
Enzyme Blend
Eupatorium
Elemi
Embelia
Eugenol
Fig
Goldthread
Lotus
Lily
Mistletoe
Mimosa
Oak
Orchid
Poppy
Rose
Spikenard
Snakeroot (unspecified)
Sweet Orange alcohol
Vervain
walnut

Other health conditions supported by vitamin D

Acne
Allergies (food)
Allergies (respiratory)
Alzheimer's Disease
Amenorrhea
Anemia
Anorexia
Apathy
Arrhythmia
Arteriosclerosis
Arthritis
Asthma
Autism
Autoimmune Disorders
Backache
Birth Defects (prevention)
Body Building
Broken Bones
Calcium Deficiency
Cancer (natural therapy for)
Cancer (prevention)
Cancer Treatment (reducing side effects)
Cardiovascular Disease
Celiac Disease
Chronic Obstructive Pulmonary Disorder
Colds (antiviral)
Colds (general)
Colds (prevention)
Colds (with fever)
Concentration (poor)
Concussions
Confusion
Congestive Heart Failure
Contagious Diseases
Convalescence
Convulsions
Cramps (menstrual)
Cramps and Spasms
Crohn's Disease
Cystic Breast Disease
Cystic Fibrosis
Dandruff
Debility
Dementia
Depression
Dermatitis
Diabetes
Diabetic Retinopathy
Erectile Dysfunction
Estrogen (low)
Fatigue
Fibroids (uterine)
Fibromyalgia Syndrome
Fibrosis
Grave's Disease
Grief and Sadness
Hair (loss or thinning)
Hair Care (general)
Hashimoto's Disease
Headache (cluster)
Heart (weakness)
Hypertension
Hypothyroid
Infection
Infection (bacterial)
Infection (viral)
Infertility
Inflammation
Inflammatory Bowel Disorders
Influenza
Injuries
Irritable Bowel Syndrome
Itching
Knees (weak)
Leaky Gut Syndrome
Leprosy
Lesions
Leukemia
Lou Gehrig's Disease
Lupus
Lymphoma
Melanoma
Memory and Brain Function
Menopause
Menstrual Irregularity
Mental Illness
Metabolic Syndrome
Migraine
Miscarriage (prevention)
Mood Swings
Multiple Sclerosis
Muscle Tone (lack of)
Muscular Dystrophy
Myasthenia Gravis
Nephritis
Nerve Damage
Nervous Exhaustion
Numbness
Nursing
Obsessive Compulsive Disorder
Oral Surgery
Osteoporosis
Pain (general remedies for)
Pancreatitis
Paralysis
Parkinson's Disease
Peripheral Neuropathy
PMS (general)
PMS Type D
PMS Type H
PMS Type P
PMS Type S
Pneumonia
Polyps
Post Partum Depression
Post Partum Weakness
Pregnancy (herbs and supplements for)
Progesterone (low)
Prostatitis
Psoriasis
Rheumatoid Arthritis
Schizophrenia
Sciatica
Seasonal Affective Disorder
Senility
Tuberculosis