Evidence supporting the use of: Vitamin B9 (methyltetrahydrofolate)
For the body system: Ovaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B9, especially in the form of methyltetrahydrofolate (the active, bioavailable form), is scientifically validated as important for ovarian health and function. Folate is essential for DNA synthesis, repair, and methylation, all of which are vital processes in ovarian cells due to the rapid cell division that occurs during oocyte (egg) maturation and ovulation. Adequate folate levels are associated with improved fertility outcomes, including higher rates of ovulation and conception. Studies have shown that women with low folate status may experience irregular ovulation and a higher risk of neural tube defects if they conceive. Supplementation with folate is also recommended for women trying to conceive and during early pregnancy to prevent fetal neural tube defects, indirectly supporting ovarian and reproductive health by ensuring the proper environment for conception and early embryonic development.

Methyltetrahydrofolate, as opposed to synthetic folic acid, is particularly relevant for individuals with polymorphisms in the MTHFR gene, which impairs folic acid metabolism. For these women, using the methylated form ensures proper folate activity in the body, supporting cellular functions in the ovaries. While the direct impact of methyltetrahydrofolate specifically on ovarian health requires further research, the role of folate in female reproductive biology is well established, justifying its use for supporting the ovarian system.

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