Evidence supporting the use of: Vitamin B9 (folic acid/folate)
For the body system: Ovaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B9, also known as folic acid (synthetic form) or folate (natural form), is scientifically validated as important for ovarian and overall reproductive health, particularly in the context of preconception and pregnancy. Folate is essential for DNA synthesis, repair, and methylation, processes that are especially critical during the rapid cell division involved in oocyte (egg) maturation and early embryonic development. Scientific studies have shown that low folate status may be associated with an increased risk of ovulatory infertility. Supplementation with folic acid is strongly recommended for women of reproductive age, not only to reduce the risk of neural tube defects in the fetus but also to support healthy ovarian function and ovulation. Some research suggests that adequate folate intake may improve fertility outcomes and oocyte quality, especially in women undergoing assisted reproductive technologies. The evidence base includes epidemiological studies, randomized controlled trials, and mechanistic research, lending substantial support (but not absolute proof) to folate’s role in ovarian health. However, its primary clinical justification remains the prevention of neural tube defects, with ovarian support being a secondary benefit. Overall, folate is scientifically validated as supportive for the ovarian system, particularly in women planning pregnancy.

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