Evidence supporting the use of: Vitamin B9 (calcium methyltetrahydrofolate)
For the body system: Ovaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B9, also known as folate or folic acid, and specifically as calcium methyltetrahydrofolate in supplement form, has strong scientific backing for its role in supporting ovarian and overall female reproductive health. Folate is crucial for DNA synthesis, cell division, and tissue growth, all of which are essential processes for ovarian function, oocyte quality, and fertility. Numerous studies have demonstrated that adequate folate levels are associated with improved ovulation, reduced risk of neural tube defects in early pregnancy, and better outcomes in assisted reproductive technologies such as IVF. Women of reproductive age are advised to ensure sufficient folate intake before and during pregnancy to reduce the risk of birth defects and support healthy ovarian function. Methyltetrahydrofolate, the active form of folate, is especially beneficial for individuals with MTHFR gene mutations, which can impair folic acid metabolism. While research primarily focuses on folate’s role in pregnancy and neural tube defect prevention, there is growing evidence that it also supports ovarian reserve and hormone regulation. Thus, the use of calcium methyltetrahydrofolate to support the ovaries is well-supported by scientific evidence, particularly in the context of fertility and reproductive health.

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