Evidence supporting the use of: L-carnitine
For the body system: Ovaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-carnitine is a naturally occurring amino acid derivative that plays a key role in energy metabolism, particularly in the transport of fatty acids into mitochondria for beta-oxidation. Its use in supporting ovarian function has been the subject of several scientific studies, particularly in the context of female infertility and polycystic ovary syndrome (PCOS). Clinical research has shown that L-carnitine supplementation may improve ovulatory function, oocyte quality, and pregnancy rates in women with infertility issues, especially when combined with other treatments such as clomiphene citrate. The proposed mechanisms include improving mitochondrial function, reducing oxidative stress, and enhancing lipid metabolism within ovarian tissue. Several randomized controlled trials and meta-analyses suggest that L-carnitine may help reduce insulin resistance and androgen levels in women with PCOS, which can, in turn, support more regular ovulation and hormone balance. However, while the evidence is promising, it is not yet definitive, and larger, well-controlled studies are still needed to firmly establish its efficacy and optimal dosing. Overall, L-carnitine is used with some scientific support for ovarian health, particularly in the context of reproductive challenges and metabolic disturbances associated with PCOS.

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