Evidence supporting the use of: Gamma Linolenic Acid
For the body system: Ovaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Gamma Linolenic Acid (GLA) is an omega-6 fatty acid found in plant oils such as evening primrose oil, borage oil, and black currant seed oil. Its use to support the ovaries and women's reproductive health stems primarily from its role in modulating inflammation and prostaglandin synthesis, which are thought to influence menstrual health and symptoms associated with premenstrual syndrome (PMS) and menopause. Several small clinical trials have investigated the effects of GLA-containing oils, particularly evening primrose oil, for PMS and cyclical breast pain (mastalgia), both of which are related to ovarian hormonal fluctuations. Results from these studies are mixed, with some showing modest benefits and others finding no significant effect compared to placebo. There is limited direct research on GLA’s impact on overall ovarian function or health (such as ovulation or hormone production), but its proposed mechanism—altering the balance of prostaglandins—provides a plausible rationale for its traditional use in women's health. Major scientific reviews conclude that while GLA may have some benefit for PMS symptoms, the evidence is insufficient and not robust. Therefore, the use of GLA to support the ovaries can be considered to have a limited scientific basis (evidence rating: 2/5), with more research needed to confirm its effectiveness and clarify mechanisms of action.

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