Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polysaccharides, particularly those derived from medicinal plants and fungi (such as Ganoderma lucidum, Lycium barbarum, and others), have been investigated for their potential role in supporting bone health and treating osteoporosis. Scientific studies, primarily in vitro and in animal models, suggest that certain polysaccharides may improve osteoblast activity, inhibit osteoclast differentiation, and modulate inflammatory and oxidative stress pathways involved in bone metabolism. For example, polysaccharides from Lycium barbarum (goji berry) have been shown in preclinical studies to increase bone mineral density and improve bone microarchitecture in ovariectomized rats, a common model for postmenopausal osteoporosis. Similarly, some fungal polysaccharides have demonstrated the ability to enhance bone formation and reduce bone resorption.

However, despite these promising preclinical findings, robust clinical evidence in humans is lacking. Most current data come from animal studies or small pilot trials. There are very few large-scale, randomized controlled trials examining the efficacy of polysaccharides for osteoporosis in humans. Thus, while there is a scientific rationale and some supportive experimental evidence, the overall quality and quantity of evidence are low, and more research is needed before polysaccharides can be recommended as a standard treatment for osteoporosis.

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