The use of New Zealand Green Lipped Mussel (Perna canaliculus) for osteoporosis is primarily supported by limited scientific evidence rather than traditional use. Green Lipped Mussel extracts are better known for their anti-inflammatory properties and are most commonly studied in the context of osteoarthritis and joint pain, not osteoporosis specifically. Some preclinical studies suggest that components of the mussel, such as omega-3 fatty acids, glycosaminoglycans, and other bioactive lipids, may have a positive effect on bone metabolism, potentially slowing bone loss or supporting bone health. However, direct clinical evidence in humans regarding osteoporosis prevention or treatment is sparse.

A handful of animal studies have indicated that supplementation can influence bone density and markers of bone turnover, likely due to the anti-inflammatory effects and possibly through promoting bone formation. However, there are no robust, well-controlled human clinical trials demonstrating a clear benefit for osteoporosis. Most scientific reviews and authoritative sources do not currently recommend Green Lipped Mussel as a primary or adjunct therapy for osteoporosis.

In summary, while there is a biological rationale for potential benefit and limited early-stage scientific exploration, the current evidence is weak (rating: 1/5), and Green Lipped Mussel is not considered a validated or mainstream treatment for osteoporosis.