Evidence supporting the use of: Magnesium citrate malate
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Magnesium citrate malate is a bioavailable form of magnesium, and magnesium itself plays a critical role in bone health. Scientific evidence indicates that magnesium is an essential mineral for bone formation, as it is involved in the structural development of bone and influences the activities of osteoblasts and osteoclasts. Epidemiological studies have shown that low magnesium intake is associated with lower bone mineral density and an increased risk of osteoporosis. Some interventional studies suggest that magnesium supplementation can improve bone mineral density, particularly in postmenopausal women, though the data are not as robust or consistent as that for calcium or vitamin D.

Magnesium citrate malate, specifically, is valued for its high bioavailability, meaning it is well absorbed in the gastrointestinal tract. While most clinical studies have used various forms of magnesium, there is a scientific rationale for using highly bioavailable forms like citrate malate to ensure sufficient magnesium status. However, studies directly evaluating magnesium citrate malate for osteoporosis are limited; most research refers to magnesium more generally.

Overall, the evidence supporting magnesium supplementation in osteoporosis is moderate, with some clinical and mechanistic data suggesting benefit, but more large-scale, well-controlled trials are needed. The use of magnesium citrate malate is justified by its bioavailability and by extrapolation from studies on magnesium supplementation and bone health.

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