Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Apigenin is a naturally occurring flavonoid found in various fruits, vegetables, and herbs such as parsley, chamomile, and celery. Its potential use in supporting or treating osteoporosis has been explored primarily in preclinical studies rather than clinical human trials. The scientific rationale for apigenin’s use in osteoporosis centers on its anti-inflammatory and antioxidant properties, as well as its ability to modulate bone metabolism. Animal studies and in vitro experiments have demonstrated that apigenin can inhibit osteoclastogenesis (the formation of bone-resorbing cells) and promote osteoblast differentiation (the formation of bone-building cells). For example, research published in Phytomedicine (2018) and Journal of Cellular Physiology (2019) demonstrated that apigenin suppressed RANKL-induced osteoclast formation and bone resorption in mouse models, suggesting a protective effect against bone loss.

Despite promising laboratory and animal data, there is a lack of robust clinical trials in humans to confirm these effects. Therefore, while there is scientific interest and some supporting evidence from experimental models, the overall quality and applicability of the evidence to human osteoporosis management is limited. Apigenin is not currently recommended as a standalone or primary therapy for osteoporosis, but it remains a compound of research interest, particularly for its potential as an adjunct in bone health strategies.

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