Bifidobacterium bifidum has some scientific evidence supporting its use as an adjunct in oral surgery, primarily due to its probiotic properties. Probiotics, including B. bifidum, have been investigated for their role in modulating oral microbiota, reducing inflammation, and promoting healing following oral surgical procedures such as tooth extractions, periodontal surgeries, and implant placements.

Several small clinical studies and pilot trials have found that probiotic supplementation can reduce postoperative complications like infection, swelling, and delayed healing. B. bifidum and other probiotic strains may inhibit pathogenic bacteria in the oral cavity, support the regeneration of oral tissues, and reduce the risk of secondary infections. For example, a few randomized controlled trials have demonstrated reduced postoperative pain and swelling in patients using probiotic lozenges or rinses that include B. bifidum after oral surgery.

However, while the mechanistic rationale is strong, the overall quality and quantity of direct clinical evidence specifically for B. bifidum in oral surgery patients remains limited. Most studies are small, short-term, or use mixtures of probiotic strains, making it difficult to isolate the effect of B. bifidum alone. Therefore, while there is some scientific basis for its use, it is not yet established as a standard of care, and more robust clinical trials are needed.