Bovine liver has a long history of use as a nutrient-dense food, but its application in supporting the nervous system is primarily grounded in its nutritional profile. Scientific validation exists mainly in the context of the liver's high content of essential nutrients such as vitamin B12, folate, iron, and choline. Vitamin B12 and folate are crucial for the synthesis of neurotransmitters, the maintenance of myelin sheaths, and the prevention of neurological disorders such as peripheral neuropathy and cognitive decline. Choline, another component abundant in liver, is a key precursor for acetylcholine, a neurotransmitter involved in memory and muscle control. Iron, also present in significant amounts, is important for oxygen transport and brain function.

Several human studies have confirmed that deficiencies in these nutrients can lead to neurological symptoms, and supplementation can reverse or prevent such issues. However, direct clinical trials using bovine liver as an intervention for neurological conditions are lacking. Most evidence relates to nutrient content rather than liver extracts or supplements per se. While traditional systems have valued liver for general vitality, the scientific rationale for its benefits to the nervous system primarily revolves around its micronutrient density rather than specific bioactive compounds unique to bovine liver.