Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-alanyl-L-glutamine is a dipeptide composed of the amino acids alanine and glutamine, commonly used in clinical nutrition and sports supplements. Its primary rationale for supporting the muscle system is based on its ability to provide a stable, soluble form of glutamine, an amino acid that is conditionally essential during periods of metabolic stress, such as intense exercise or trauma.

Several studies indicate that L-alanyl-L-glutamine supplementation can help maintain muscle glutamine stores, support muscle protein synthesis, and reduce muscle breakdown, particularly in situations of prolonged endurance exercise or critical illness. The dipeptide form is more stable than free glutamine, which tends to degrade in solution, and is absorbed efficiently via peptide transporters in the gut.

Clinical research in athletes shows that L-alanyl-L-glutamine supplementation may help with muscle recovery, reduce muscle soreness, and improve exercise performance in endurance settings, although findings are mixed and benefits are modest. In clinical settings, it is used to prevent muscle wasting in critically ill patients and to promote nitrogen balance. However, the magnitude of effects in healthy, resistance-trained individuals is less clear, and the routine use for muscle building in the general population is not strongly supported.

Overall, there is scientific validation for its role in supporting muscle health under specific conditions, but the evidence is moderate, and more research is needed for widespread use in sports nutrition.

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