Hairy Arnica (Arnica mollis), like its more commonly studied relative Arnica montana, has a traditional use in herbal medicine, primarily among North American indigenous peoples and in folk herbalism, as a topical remedy for muscle aches, bruises, sprains, and general muscle soreness. Applications typically involve poultices, salves, or ointments made from the flowers, which are believed to reduce inflammation and promote healing of muscle tissue following trauma or overexertion.

While the traditional use is well documented, rigorous scientific studies specifically on Hairy Arnica (Arnica mollis) are lacking. Most modern research and clinical trials focus on Arnica montana, which contains similar compounds (such as sesquiterpene lactones, flavonoids, and essential oils) believed to have anti-inflammatory and analgesic effects when applied topically. Nevertheless, the pharmacological activity of Arnica mollis itself has not been directly validated in controlled studies. Thus, the use of Hairy Arnica to support the muscles body system is primarily justified by tradition rather than current scientific evidence.

Internal use of any arnica species is not recommended due to potential toxicity. Topical preparations, when used appropriately, are rooted in traditional practice, but scientific validation for Arnica mollis specifically remains insufficient.