Evidence supporting the use of: GW501516
For the body system: Muscles
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
GW501516, also known as Cardarine, is a research chemical that acts as a PPARδ agonist. It has gained attention in the athletic and bodybuilding communities due to studies suggesting it can enhance endurance and promote fat burning, which indirectly supports muscle performance and body composition. Preclinical studies in rodents have shown that GW501516 increases fatty acid metabolism, improves exercise endurance, and reduces fat mass by activating the PPARδ pathway. Some early human trials and anecdotal reports also indicate potential improvements in exercise capacity and stamina.
However, GW501516 is not approved for human use by regulatory agencies like the FDA due to concerns over safety, including findings in animal studies that long-term use may increase cancer risk. There is no substantial evidence from large, well-controlled human trials to confirm its efficacy or safety for muscle support. Its use is banned by the World Anti-Doping Agency (WADA) for athletes. In summary, while some scientific studies suggest a potential benefit for muscle endurance and fat metabolism, these findings are mostly limited to animal research and small-scale studies, and the risks may outweigh the benefits.
Other ingredients that support Muscles
acetyl l-carnitineadenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
astaxanthin
beet
beta-alanine
bovine
bovine liver
branched-chain amino acids
bromelain
caffeine
calcium
cherry
chloride
coenzyme Q10 (CoQ10)
colostrum
conjugated linoleic acid (CLA)
cordyceps
creatine monohydrate
turmeric
d-alpha tocopherol
devil's claw
dong quai root
fish protein
forskohlii root
l-isoleucine
iron
kale
l-alanine
l-alanyl-l-glutamine
l-arginine
l-carnitine
l-carnosine
l-citrulline
l-glutamine
l-glycine
l-leucine
l-ornithine
l-proline
l-taurine
l-threonine
l-valine
magnesium
malic acid
maltodextrin
maltose
methylsulfonylmethane (MSM)
milk
nicotinamide riboside
ornithine alpha-ketoglutarate
peppermint oil
phosphorus
phytocannabinoids
potassium
protein
quinoa
rhizome
sardines
black ginger
soybean
specialized pro-resolving mediators (SPMs)
spinach
spirulina
tongkat ali
ubiquinol
Urolithin A
vitamin B
vitamin C
vitamin D
vitamin D3
water
watermelon
whey protein
white willow
β-nicotinamide mononucleotide (NMN)
suma
squawvine
sodium salt
solomon's seal
siler root
eucommia
electrolytes blend (proprietary)
guelder rose
polyphenols
trace minerals
wintergreen
camphor oil
menthol oil
wheat germ
wood betony
herbal blend (proprietary)
algae
chickpea protein
brown rice protein
AMP-activated protein kinase (AMPK)
arnica
17 alpha methyl 17 beta hydroxy 5 alpha androst 2 ene
17a-di methyl-bol
11-Ketotestosterone
2, 17a-dimethyl-17b-hydroxy-5a-androstan-1-ene-3-one
2a, 17a-dimethyl-17b-hydroxy-5a-androstan-3-one
Arginine Alpha Ketoglutarate
Animal Tissue
Antler
Arginine Creatine
Arginine nitrate
Arachidonic Acid
Arginine malate
Arginine aspartate
Avocado
Anserina
Alpha-ketoisocaproic acid
Acetylcholine
adenosine triphosphate (ATP)
Algal protein
Alpha hydroxyisocaproic acid
Arginine alpha-ketoisocaproate
Arginine silicate
Animal protein
Blue Cohosh
Biopeptide
Beta-hydroxybutyrate
Bicarbonate
Beef Protein
Black galingale
Beef
Beef liver
Bovine Protein
Black Gram
Black willow
Ba Ji Tian
Bee products
banana
BCAA
Chia seed
Casein
Cardarine
Chinese Mountain Ant
Carnosine
Citrate malate
Cyathula
Curcuminoid
Cramp Bark
Chuchuhuasi
Cyanotis Vaga
Coca
Coconut Water
Cetylated Fatty Acids
Creatine
Chicken
Curcuma
C-Phycocyanin
Cyanotis arachnoides
DL-Methionine
Deer Velvet
Date
D-Ribose
Dextrose
Dimethyl sulfoxide (DMSO)
Dipsacus
Dipeptide
epicatechin
Epistane
Egg
Erythrina
Elk antler
Eurycoma Longifolia
Emu Oil
Ecdysteroids
Elthyl-Alpha-Guanido-Methyl-Ethanoate
Ecdysterone
Essential Oil Blend
Egg protein
Fish
Fatty acids
fibroblast growth factor
Guanidinoacetic acid
Ginsenosides
Glutamine
GMS-ribose
glucose
Glycocyamine
Glycerol
Glycine
Guanidinopropionic Acid (GPA )
Isoleucine
Milk Protein
Phosphate Salt
Potash
Quinoa Protein
Shellfish
salt
Soy Protein
Tribulus Terrestris
