Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Creatine alpha-ketoglutarate is a compound formed by combining creatine with alpha-ketoglutarate, a molecule involved in the Krebs cycle. Creatine itself is one of the most extensively studied supplements for enhancing muscle performance, primarily due to its role in rapid ATP regeneration during high-intensity, short-duration activities such as weightlifting or sprinting. Numerous studies have shown that creatine monohydrate supplementation can increase muscle mass, strength, and anaerobic performance. However, creatine alpha-ketoglutarate is a less commonly studied form compared to creatine monohydrate or creatine ethyl ester. The rationale for combining creatine with alpha-ketoglutarate is largely to improve absorption or offer synergistic benefits, as alpha-ketoglutarate is involved in energy metabolism and may aid in reducing muscle fatigue. Some supplement manufacturers claim that this combination enhances muscle uptake of creatine, but direct, peer-reviewed evidence for creatine alpha-ketoglutarate specifically is limited. Most of the scientific validation for muscle health and performance enhancement comes from studies on creatine in general, not this specific salt. In summary, while creatine (in general) is scientifically validated for supporting muscle health and performance, creatine alpha-ketoglutarate has less direct evidence supporting its unique benefits. Its use for the muscle system is therefore justified by the scientific backing for creatine overall, but not specifically for this form.

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