Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cannabinoids, particularly those derived from cannabis such as cannabidiol (CBD) and tetrahydrocannabinol (THC), have been investigated for their effects on the muscular system, mainly in the context of muscle spasticity and pain management rather than direct muscle strengthening or growth. The most well-established use is the reduction of muscle spasticity in conditions like multiple sclerosis (MS), where several clinical trials and systematic reviews have demonstrated modest efficacy of cannabinoid-based medicines in reducing spasticity symptoms compared to placebo. The mechanism is thought to involve modulation of the endocannabinoid system, which influences neurotransmitter release and muscle tone regulation.

For general muscle recovery or support in healthy individuals, the evidence is sparse and largely preclinical or anecdotal. Some studies suggest cannabinoids may reduce inflammation and pain post-exercise, potentially aiding recovery, but robust, large-scale clinical trials are lacking. Therefore, while there is scientific validation for the use of cannabinoids to manage muscle spasticity in neurological conditions, there is limited and low-quality evidence supporting their use for general muscle health or athletic recovery.

References:
- Koppel BS, et al. "Systematic review: efficacy and safety of medical marijuana in selected neurologic disorders." Neurology. 2014.
- Nielsen S, et al. "Cannabis for spasticity in multiple sclerosis or paraplegia." Cochrane Database Syst Rev. 2018.

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