Evidence supporting the use of: Vitamin B12 (mixed)
For the health condition: Multiple Sclerosis
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Vitamin B12 (cobalamin) has been explored in relation to multiple sclerosis (MS) due to its essential role in myelin synthesis and neurological function. Scientific studies have consistently shown that B12 deficiency can lead to neurological symptoms that may mimic or worsen MS. However, most patients with MS do not have a true B12 deficiency, and current research does not support the routine use of B12 supplementation for all MS patients. Some small studies and case reports from the 1980s and 1990s suggested that B12 injections might help with fatigue or neurological symptoms in MS, but these were often uncontrolled and not rigorously designed. A few more recent studies have examined B12 levels in MS patients, finding that low or borderline B12 is not uncommon, but interventional studies are lacking or inconclusive regarding benefit for MS-specific symptoms or disease progression. Major MS guidelines do not recommend B12 supplementation unless there is laboratory-confirmed deficiency. In summary, while there is a clear scientific rationale for correcting B12 deficiency in MS patients, there is insufficient high-quality evidence to support B12 supplementation as a treatment or disease-modifying therapy for MS in individuals with normal B12 levels.
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