Panthenol, also known as provitamin B5, is widely recognized for its moisturizing and healing properties in dermatology and cosmetic products. Its use to support mucus membranes is scientifically justified, primarily through its role in promoting epithelialization, hydration, and repair of mucosal tissues. Several studies have shown that topical application of panthenol can aid in the regeneration and maintenance of the mucosal barrier, particularly in the oral and nasal cavities. For example, clinical trials have demonstrated that panthenol-containing formulations can reduce symptoms of oral mucositis, accelerate healing of aphthous ulcers, and alleviate dryness and irritation of the nasal mucosa.

The mechanism involves panthenol's conversion to pantothenic acid (vitamin B5) in the tissues, which is essential for coenzyme A synthesis and cellular metabolism. This supports the maintenance and repair of epithelial cells lining the mucus membranes. Additionally, panthenol has anti-inflammatory effects, which can further benefit irritated or damaged mucosal surfaces.

While the strongest evidence comes from topical and oral care studies, panthenol is also included in some nasal sprays and lozenges for its soothing effects. However, more large-scale, high-quality clinical trials would be beneficial to further confirm its efficacy and optimize formulations. Overall, current evidence supports the use of panthenol as a supportive agent for mucus membrane health, especially in promoting healing and hydration.