Heliopsis, commonly referred to as "oxeye" or "false sunflower," is a genus of plants native to the Americas. Its use in supporting the mucus membranes—lining tissues in the respiratory, digestive, and other tracts—stems primarily from traditional medicine, especially among Indigenous peoples in Mexico and Central America. Ethnobotanical records indicate that Heliopsis species, particularly Heliopsis longipes (commonly known as "chilcuague" or "golden root"), have been used traditionally to soothe sore throats, relieve oral discomfort, and support oral and respiratory health. These uses are generally attributed to the plant’s numbing and tingling effects when chewed, believed to protect and comfort mucosal tissues.

While there is some preliminary research into the antimicrobial and analgesic properties of Heliopsis extracts, robust clinical evidence directly supporting its use for mucus membrane health is lacking. The primary justification for its use is based on longstanding traditional practices and anecdotal evidence rather than rigorous scientific validation. As such, the rating is a 2, reflecting the presence of a traditional basis and some plausible biological activity, but an absence of strong clinical trials or scientific consensus.