Coltsfoot (Tussilago farfara) has a long history of traditional use as a remedy for ailments affecting the mucus membranes of the respiratory system, such as coughs, bronchitis, and sore throats. The leaves and flowers have been prepared as teas, syrups, or lozenges to soothe irritation and promote expectoration. Historical texts from European herbal medicine frequently mention coltsfoot for its demulcent and antitussive properties, believed to help coat and protect inflamed mucous membranes and ease respiratory discomfort.

Despite this tradition, modern scientific validation for coltsfoot's effectiveness is limited. Some laboratory studies indicate that it contains mucilage, which can have a soothing effect on tissues, as well as compounds like tussilagone that may possess mild anti-inflammatory and antitussive activity. However, there is a lack of robust clinical trials in humans to confirm its efficacy and safety for supporting mucus membranes. Additionally, coltsfoot contains pyrrolizidine alkaloids, which are potentially hepatotoxic, leading to regulatory restrictions in some countries. Overall, the use of coltsfoot for mucus membrane support remains rooted in traditional herbal practice rather than strong scientific evidence.