Evidence supporting the use of: Vitamin B3 (Niacin)
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Vitamin B3, also known as niacin, is scientifically validated as important for mitochondrial function. Niacin is a precursor to nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme found in all living cells. NAD+ is central to cellular energy metabolism, particularly in the mitochondria, where it participates in redox reactions required for ATP production via oxidative phosphorylation. Deficiency in niacin or NAD+ impairs mitochondrial function, leading to energy deficits and, in severe cases, cellular dysfunction or death.
Several studies have shown that niacin supplementation can increase NAD+ levels, which may enhance mitochondrial efficiency and resilience. In animal models and some human studies, boosting NAD+ via niacin or related compounds (such as nicotinamide riboside or nicotinamide mononucleotide) has been shown to improve mitochondrial biogenesis, reduce oxidative stress, and support overall cellular energetics. These effects are of particular interest in aging and metabolic disorders, where mitochondrial decline is a hallmark.
Although most of the clinical research is early stage and more robust human trials are needed, the biochemical role of niacin in mitochondrial health is well established. Therefore, the use of Vitamin B3 (niacin) to support mitochondrial function is supported by strong scientific rationale and preliminary evidence.
Other ingredients that support Mitochondria
7-Keto-DHEAacetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
Flavin mononucleotide
Fish
Fatty acids
Fucoxanthin
Flavones
Ginsenosides
Gamma-Glutamylcysteine
glucose
Glutathione
Guanidinopropionic Acid (GPA )
Geranylgeraniol
Ketone Salts
Other body systems supported by Vitamin B3 (Niacin)
ArteriesBlood
Brain
Capillaries
Circulatory System
Digestive System
Gastrointestinal Tract
Heart
Hepatic System
Immune System
Liver
Mitochondria
Nerves
Skin
