Evidence supporting the use of: Sulforophane
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Sulforaphane, a bioactive compound found in cruciferous vegetables like broccoli, has garnered considerable scientific interest for its effects on mitochondrial function. Research indicates that sulforaphane activates the Nrf2 pathway, which upregulates the expression of various antioxidant and cytoprotective genes. This activation enhances cellular defense mechanisms and reduces oxidative stress, both of which are critical for maintaining healthy mitochondrial function. Several in vitro and animal studies have shown that sulforaphane can improve mitochondrial biogenesis (the process by which new mitochondria are formed in the cell) and support mitochondrial respiration. For example, studies published in journals such as Free Radical Biology and Medicine and Cell Death & Disease report that sulforaphane administration increases mitochondrial mass and improves the function of mitochondria under conditions of stress or toxicity.
However, while preclinical evidence is promising, direct clinical data in humans specifically targeting mitochondrial function is limited. Most human studies have focused on broader outcomes like inflammation, oxidative stress, or metabolic parameters. Thus, while there is mechanistic and early experimental support for sulforaphane's role in supporting mitochondrial health, the evidence base is not yet robust enough to warrant a higher rating. Further clinical trials are needed to confirm these effects in human populations.
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adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
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cistanche
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fulvic acid
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5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
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Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
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Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
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Eriocitrin
Ergothioneine
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Fatty acids
Fucoxanthin
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Gamma-Glutamylcysteine
glucose
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Guanidinopropionic Acid (GPA )
Geranylgeraniol
Ketone Salts
