Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B9, particularly in its active form methylfolate (5-methyltetrahydrofolate), is scientifically recognized for its importance in pregnancy, especially for the prevention of neural tube defects. Its role in miscarriage prevention is somewhat less directly established, but there is scientific rationale and some supporting evidence. Folate is critical for DNA synthesis, repair, and methylation, all fundamental to cell division and embryonic development. Folate deficiency has been linked to increased risk of neural tube defects and possibly other adverse pregnancy outcomes. Some studies suggest that low maternal folate levels may be associated with increased risk of miscarriage, particularly in early pregnancy. Supplementation with folic acid or methylfolate before conception and during early pregnancy is widely recommended to reduce the risk of birth defects, and might incidentally lower miscarriage risk, especially in women with certain genetic polymorphisms (such as MTHFR mutations) that reduce folate metabolism efficiency. However, direct randomized controlled trials specifically evaluating methylfolate for miscarriage prevention are limited. Most guidelines and studies focus on general pregnancy health and neural tube defect prevention rather than miscarriage specifically. Thus, while there is a plausible biological basis and some associative evidence, the strength of direct scientific evidence for miscarriage prevention is moderate but not definitive.

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