Evidence supporting the use of: Vitamin D (cholecalciferol)
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D (cholecalciferol) has some scientific evidence suggesting a potential role in migraine prevention or management, though the evidence is still preliminary and not definitive. Several observational studies have reported that people with migraines are more likely to have low vitamin D levels compared to healthy controls. Some small randomized controlled trials (RCTs) have evaluated vitamin D supplementation in migraine sufferers, with a few reporting a reduction in migraine frequency or severity. For example, a 2019 meta-analysis published in Headache reviewed available RCTs and found a modest benefit of vitamin D supplementation in reducing headache frequency, but highlighted the small sample sizes and heterogeneity among studies. Proposed mechanisms include vitamin D’s anti-inflammatory properties and its role in modulating immune and neuronal functions, which may influence migraine pathophysiology.

However, current guidelines do not universally recommend vitamin D supplementation solely for migraine management, except in individuals with documented deficiency. The body of evidence remains limited by the small size and methodological limitations of most studies. In conclusion, while there is some scientific rationale and preliminary clinical data supporting vitamin D’s use for migraine, the overall evidence is weak to moderate and further large-scale, well-designed trials are needed to establish efficacy and optimal dosing.

More about Vitamin D (cholecalciferol)
More about Migraine

Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
Melatonin
Moringa
Niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Zinc
atractylodes
blackboard tree
Swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
apple cider vinegar
Albizia
alpha-lipoic acid
atractylone
betony
black seed
Baikal Skullcap
beta-hydroxybutyrate
Blepharis
balsam
banyan
brahmi
butterbur
Bifidobacteria
Black Hellebore
Chinese silkvine
crocin
creatine
cannabidiol
Corydalis
Carthamus
cola nut
docosahexaenoic Acid
danshen
eicosapentaenoic acid
folic acid
flavin mononucleotide
Ficus religiosa
fish
flavanones
Ficus simplicissima
frankincense
goldthread
Gelsemium
ginkgolides
Ginkgoside
Hellebore
iridoids
ketone salts
kuding tea
lemon balm
Lesser speargrass
little ironweed
linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Products containing Vitamin D (cholecalciferol)

We currently have no products on Caring Sunshine that contain this ingredient.