Evidence supporting the use of: Vitamin B6 (pyridoxine 5-phosphate)
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (in its active form, pyridoxal 5-phosphate) has some scientific evidence supporting its use in migraine management, though the evidence is limited and not conclusive. B6 is involved in neurotransmitter synthesis, including serotonin, which is implicated in migraine pathophysiology. Several small clinical studies and trials have investigated Vitamin B6, often in combination with other B vitamins (such as folic acid and B12), for migraine prophylaxis. A few studies, particularly those targeting individuals with elevated homocysteine levels (sometimes due to MTHFR gene mutations), have shown that B6 supplementation can reduce migraine frequency and severity. For example, a randomized controlled trial published in 2015 found that a combination of B6, B9 (folic acid), and B12 reduced migraine disability in patients with migraine with aura, likely through lowering homocysteine levels. However, Vitamin B6 alone has not been extensively studied for migraine, and most clinical trials combine B6 with other nutrients. Systematic reviews recognize the potential benefit but generally rate the evidence as low to moderate quality due to small sample sizes and methodological limitations. Thus, while there is some scientific rationale and preliminary data, Vitamin B6 should not be considered a primary standalone therapy for migraine, and more robust clinical trials are needed to establish its efficacy.

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