Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Estrogen is scientifically validated for the treatment of menstrual irregularity, especially when the underlying cause is a deficiency or imbalance of endogenous estrogens. Estrogen is a primary female sex hormone responsible for the regulation and maintenance of the menstrual cycle. In clinical practice, estrogen therapy—often as part of combined oral contraceptives or as estrogen replacement therapy—has been used for decades to manage irregular menstrual cycles, particularly those caused by conditions such as polycystic ovary syndrome (PCOS), hypothalamic amenorrhea, or perimenopause.

Numerous randomized controlled trials and clinical guidelines support the use of estrogen-containing therapies to regulate menstruation. For example, the American College of Obstetricians and Gynecologists (ACOG) endorses combined hormonal contraceptives as a first-line treatment for menstrual irregularity. These medications work by providing a steady dose of estrogen and progestin, stabilizing the endometrial lining and promoting regular withdrawal bleeding.

Estrogen therapy is also used for women with primary ovarian insufficiency or those experiencing menopausal transition, where endogenous estrogen production is inadequate. In these cases, restoring physiologic levels of estrogen can re-establish more regular menstrual bleeding patterns.

In summary, the use of estrogen for menstrual irregularity is well-substantiated by scientific research and is a standard of care in gynecology.

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