Five-leaf Chastetree (Vitex negundo) is a plant traditionally used in various Asian systems of medicine, particularly Ayurveda and traditional Chinese medicine. While its close relative, Vitex agnus-castus (Chaste Tree or Monk’s Pepper), is well-studied and commonly used in Europe for women’s hormonal health and menopause support, the evidence for Vitex negundo is less robust and primarily based on traditional usage rather than modern scientific validation.

Historical texts indicate that Vitex negundo has been used to address a range of female reproductive issues, including irregular menstruation and menopausal symptoms such as hot flashes and mood disturbances. Herbal practitioners have employed the plant’s leaves, seeds, and roots in decoctions and extracts, attributing its effects to its purported anti-inflammatory and hormone-modulating properties. However, clinical trials specifically examining Vitex negundo for menopause are lacking. Most studies focus on its analgesic, anti-inflammatory, and antioxidant activities, rather than direct effects on menopausal symptoms.

In summary, the use of Five-leaf Chastetree to support menopause is justified primarily by tradition, with limited scientific evidence and a lack of high-quality human trials validating its efficacy for this specific condition.