Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Melatonin, a hormone produced by the pineal gland, is most commonly known for its role in regulating sleep-wake cycles. However, scientific research has explored its effects on the male reproductive system. Animal and some human studies suggest melatonin may influence testicular function, sperm quality, and testosterone production, largely due to its antioxidant properties. Melatonin receptors are present in the testes, and melatonin has been shown to counteract oxidative stress, which can damage sperm cells and impair fertility. Some studies indicate that melatonin supplementation may help improve sperm motility and reduce DNA damage in sperm, particularly in situations of increased oxidative stress (e.g., varicocele, exposure to toxins).

Despite these findings, the evidence in humans is limited and somewhat inconsistent. Most clinical studies are small, and the impact of melatonin on male fertility parameters is not yet fully understood. Moreover, some research suggests that excessively high melatonin levels could potentially suppress gonadotropin-releasing hormone (GnRH), which might negatively affect reproductive hormone production. Currently, melatonin is not a mainstream or first-line supplement for male reproductive health, and its use is primarily experimental. Thus, while there is some scientific basis for its effects on the male reproductive system, the overall evidence is limited and more research is needed to draw definitive conclusions.

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